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研究一覧
抗酸化作用
Antioxidant activity of taxifolin: an activity-structure relationship.
Taxifolin protects RPE cells against oxidative stress-induced apoptosis.
Dihydroquercetin as a means of antioxidative defence in rats with tetrachloromethane hepatitis.
Taxifolin and Fucoidin Abolish the Irradiation-Induced Increase in the Production of Reactive Oxygen Species in Rat Aorta.
肝保護
Protective effects of dihydroquercetin on an APAP-induced acute liver injury mouse model.
Catechin, quercetin and taxifolin improve redox and biochemical imbalances in rotenone-induced hepatocellular dysfunction: Relevance for therapy in pesticide-induced liver toxicity?
Hepatoprotective Mechanisms of Taxifolin on Carbon Tetrachloride-Induced Acute Liver Injury in Mice.
Pretreatment with dihydroquercetin, a dietary flavonoid, protected against concanavalin A-induced immunological hepatic injury in mice and TNF-α/ActD-induced apoptosis in HepG2 cells.
抗癌性
The anti-tumor effect of taxifolin on lung cancer via suppressing stemness and epithelial-mesenchymal transition in vitro and oncogenesis in nude mice.
Taxifolin inhibits the scar cell carcinoma growth by inducing apoptosis, cell cycle arrest and suppression of PI3K/AKT/mTOR pathway.
Taxifolin Inhibits 7,12-Dimethylbenz(a)anthracene-induced Breast Carcinogenesis by Regulating AhR/CYP1A1 Signaling Pathway.
Plant flavonoid taxifolin inhibits the growth, migration and invasion of human osteosarcoma cells.
Taxifolin suppresses UV-induced skin carcinogenesis by targeting EGFR and PI3-K.
Taxifolin suppresses rat and human testicular androgen biosynthetic enzymes.
Taxifolin binds with LXR (α & β) to attenuate DMBA-induced mammary carcinogenesis through mTOR/Maf-1/PTEN pathway.
Taxifolin inhibits breast cancer cells proliferation, migration and invasion by promoting mesenchymal to epithelial transition via β-catenin signaling.
心血管
Taxifolin protects against cardiac hypertrophy and fibrosis during biomechanical stress of pressure overload.
Taxifolin alleviates apoptotic injury induced by DEHP exposure through cytochrome P450 homeostasis in chicken cardiomyocytes.
Taxifolin protects rat against myocardial ischemia/reperfusion injury by modulating the mitochondrial apoptosis pathway.
Dihydroquercetin (DHQ) induced HO-1 and NQO1 expression against oxidative stress through the Nrf2-dependent antioxidant pathway.
抗炎症
Effects of Taxifolin on Osteoclastogenesis in vitro and in vivo.
Anti-inflammatory activity of taxifolin.
Effect of taxifolin on methanol-induced oxidative and inflammatory optic nerve damage in rats.
Inhibitory effect of taxifolin on mast cell activation and mast cell-mediated allergic inflammatory response.
Protective mechanism of Taxifolin for chlorpyrifos neurotoxicity in BV2 cells.
抗菌性
Antimicrobial activity against Streptococcus sobrinus and glucosyltransferase inhibitory activity of taxifolin and some flavanonol rhamnosides from kempas (Koompassia malaccensis) extracts.
Dihydroquercetin, the bioactive substance, to be used against pathogenic microorganisms as an alternative to antibiotics.
重金属に対する保護効果
Taxifolin ameliorates iron overload-induced hepatocellular injury: Modulating PI3K/AKT and p38 MAPK signaling, inflammatory response, and hepatocellular regeneration.
Cytoprotective effects of taxifolin against cadmium-induced apoptosis in human keratinocytes.
A study on the protective effects of taxifolin on human umbilical vein endothelial cells and THP-1 cells damaged by hexavalent chromium: a probable mechanism for preventing cardiovascular disease induced by heavy metals.
Taxifolin mitigates oxidative DNA damage in vitro and protects zebrafish (Danio rerio) embryos against cadmium toxicity.